Gap junction and diabetic foot.
- Author:
Xiao-rong ZOU
1
;
Jian TAO
1
;
Yun-kai WANG
2
Author Information
1. Department of Hypertension Institute, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
2. Department of Cardiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
- Publication Type:Journal Article
- MeSH:
Atherosclerosis;
Connexins;
metabolism;
Diabetic Foot;
pathology;
Gap Junctions;
metabolism;
Humans;
Hyperglycemia;
physiopathology;
Regeneration;
Wound Healing
- From:
Journal of Zhejiang University. Medical sciences
2015;44(6):684-688
- CountryChina
- Language:Chinese
-
Abstract:
Gap junctions play a critical role in electrical synchronization and exchange of small molecules between neighboring cells; connexins are a family of structurally related transmembrane proteins that assemble to form vertebrate gap junctions. Hyperglycemia changes the structure gap junction proteins and their expression, resulting in obstruction of neural regeneration, vascular function and wound healing, and also promoting vascular atherosclerosis. These pathogenic factors would cause diabetic foot ulcers. This article reviews the involvement of connexins in pathogenesis of diabetic foot.
