Association of neuroendocrine differentiation with progression and prognosis of gastric adenocarcinoma.

Fangying XU; Qin Liu; Fengyan Han; Enping XU; Maode Lai; Zhongsheng Zhao

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Association of neuroendocrine differentiation with progression and prognosis of gastric adenocarcinoma.

Author: Fangying XU ¹ ; Qin LIU ¹ ; Fengyan HAN ¹ ; Enping XU ¹ ; Maode LAI ¹ ; Zhongsheng ZHAO ²
Author Information

1. Key Laboratory of Disease Proteomics of Zhejiang Province, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, China.
2. Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Publication Type:Journal Article
MeSH: Adenocarcinoma; diagnosis; pathology; Biomarkers, Tumor; metabolism; Chromogranin A; metabolism; Disease Progression; Humans; Immunohistochemistry; Lymphatic Metastasis; Neoplasm Staging; Neuroendocrine Tumors; diagnosis; pathology; Prognosis; Proportional Hazards Models; Retrospective Studies; Secretagogins; metabolism; Stomach Neoplasms; diagnosis; pathology; Synaptophysin; metabolism
From: Journal of Zhejiang University. Medical sciences 2016;45(1):24-30
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the association of neuroendocrine differentiation with progression and prognosis of gastric adenocarcinoma.
METHODSClinicopathological data of 240 patients with gastric adenocarcinomas were retrospectively analyzed. The expression of chromogranin A, synaptophysin and secrectagogin in cancer tissue was assessed by immunohistochemistry. The association of neuoroendocrine differentiation parameters with disease progression and survival of patients was analyzed.
RESULTSThe expression of synaptophysin was positively correlated with depth of invasion and secretagogin more often expressed in cases with lymph node metastasis. In Lauren diffuse type of cancer, expression of chromogranin A and secretagogin was unfavorable prognostic predictor. In TNM stage II adenocarcinoma, expression of chromogranin A and synaptophysin related to poor survival, and multivariate Cox proportional hazard model showed that synaptophysin was an independent predictor for poor survival.
CONCLUSIONNeuroendocrine differentiation predicts deeper depth of invasion, more possibility of lymph node metastasis and poor survival in gastric adenocarcinoma.