The state of the art of imaging in gastroenteropancreatic neuroendocrine tumors.
- Author:
Xiaochen YAO
1
;
Feng WANG
1
Author Information
1. Department of Nuclear Medicine, Clinical Center of Respiratory Disease and Imaging, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
- Publication Type:Journal Article
- MeSH:
Diagnostic Imaging;
methods;
Endoscopy;
Gallium Radioisotopes;
chemistry;
Humans;
Intestinal Neoplasms;
diagnosis;
Magnetic Resonance Imaging;
Neuroendocrine Tumors;
diagnosis;
Pancreatic Neoplasms;
diagnosis;
Prognosis;
Receptors, G-Protein-Coupled;
chemistry;
Stomach Neoplasms;
diagnosis;
Tomography, X-Ray Computed;
Ultrasonography
- From:
Journal of Zhejiang University. Medical sciences
2016;45(1):51-55
- CountryChina
- Language:Chinese
-
Abstract:
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are neoplasms presenting unpredictable and unusual biologic behavior that causes many clinical challenges. NETs can produce a variety of metabolically active substances (hormones and amines) leading to distinct clinical syndromes. This review will discuss the imaging techniques for the diagnosis of GEP-NETs including ultrasonography, CT, MRI and ultrasound endoscope. In this article, Gallium-68 labeled peptide binding to G protein coupled receptor including SSTR, CCKR1 and GLP1R is addressed, and the application of Gallium-68 labeled somatostin analogues and PET-CT for diagnosis of GEP-NETs is evaluated. In conclusion, Gallium-68 labeled peptide and molecular imaging will play important roles in diagnosis, prognosis and therapeutic strategy development of GEP-NETs.
