Location and functions of secretagogin protein.
- Author:
Qin LIU
1
;
Maode LAI
1
Author Information
1. Key Laboratory of Disease Proteomics of Zhejiang Province, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
diagnosis;
Biomarkers;
analysis;
Brain Ischemia;
diagnosis;
Calcium;
metabolism;
Hippocampus;
metabolism;
Humans;
Neuroendocrine Tumors;
diagnosis;
Secretagogins;
physiology;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2016;45(1):56-60
- CountryChina
- Language:Chinese
-
Abstract:
Secretagogin (SCGN) is a novel member of EF-hand Ca2+-binding proteins, which was identified in islet β cells by Wagner. SCGN is a six EF-hand Ca2+-binding protein, primarily expressed on the neuroendocrine axis and the central nervous system. The protein has abundant biological functions. A certain concentration of calcium ion can lead to conformation change of SCGN, resulting in the change of intracellular signal transduction. Preliminary studies showed that SCGN would be used to treat stress reaction, such as mental illness (depression), burns or post-traumatic stress disorder and chronic stress reaction caused by pain. In Alzheimer's disease, the expression of SCGN in the hippocampus can boycott neurodegeneration. In neuroendocrine tumors, SCGN presents a good consistency with neuroendocrine markers such as CgA, Syn, and NSE, with a higher overall sensitivity and specificity. In addition, SCGN is released into serum after neural damage in cerebral ischemic diseases, suggesting that SCGN can be used as a marker for brain trauma. In this article, we review the recent research progress of secretagogin, focus on its distribution and functions in various tumorous diseases and non-tumorous diseases, such as Alzheimer's disease.
