Transcatheter delivery of recombinant adenovirus vector containing exogenous aquaporin gene in treatment of Sjögren's syndrome.
- Author:
Hong HE
1
;
Jieqiong ZHANG
1
;
Yan FAN
2
;
Xiaoshuang SUN
1
;
Yuhao ZHU
1
Author Information
1. Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
2. Hangzhou Stomatology Hospital, Hangzhou 310006, China.
- Publication Type:Journal Article
- MeSH:
Adenoviridae;
Aquaporins;
genetics;
Autoimmune Diseases;
therapy;
Catheters;
Genetic Therapy;
Genetic Vectors;
administration & dosage;
Humans;
Sjogren's Syndrome;
therapy
- From:
Journal of Zhejiang University. Medical sciences
2016;45(1):86-97
- CountryChina
- Language:Chinese
-
Abstract:
Sjögren's syndrome is a kind of autoimmune disease, whose main clinical symptoms are dry mouth, dry eye and chronic parotid glandular inflammation. The conservative treatments include artificial tears or saliva,oral administration of corticosteroids,and immunosuppressantsl with limited effectiveness. Along with the development of molecular biology, vast attentions are being paid to researches on gene therapy for Sjögren's syndrome, hopefully to bring gospel to patients with Sjögren's syndrome. This article reviews the recent research progresses on transcatheter delivery of recombinant adenovirus vector with aquaporin gene in experimental treatment of Sjögren's syndrome.
