Progress on clinical application of bevacizumab for the treatment of refractory cervical cancer.
- Author:
Bin HE
1
;
Yanlan CHAI
1
;
Tao WANG
1
;
Zhenxing ZHOU
2
;
Zi LIU
3
Author Information
1. Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China.
2. Shanghai Roche Pharmaceutucals Ltd., Shanghai 201203, China. zhenxing.zhou@roche.com.
3. Department of Radiation Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China. liuzmail@163.com.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Combined Chemotherapy Protocols;
economics;
therapeutic use;
Bevacizumab;
economics;
therapeutic use;
Cost-Benefit Analysis;
Female;
Fluorouracil;
economics;
therapeutic use;
Health Care Costs;
Humans;
Neoplasm Recurrence, Local;
drug therapy;
Paclitaxel;
economics;
therapeutic use;
Remission Induction;
Retrospective Studies;
Survival Rate;
Treatment Outcome;
Uterine Cervical Neoplasms;
drug therapy;
economics;
mortality
- From:
Journal of Zhejiang University. Medical sciences
2016;45(4):395-402
- CountryChina
- Language:Chinese
-
Abstract:
Bevacizumab is increasingly used in recurrent, persistent or metastatic cervical cancer. The early retrospective case reports found that bevacizumab combined with 5-FU (including capecitabine) or paclitaxel was well tolerated and displayed encouraging anti-tumor activity in recurrent or persistent cervical cancer. Phase Ⅱ clinical trials showed that bevacizumab was well tolerated and active in the second- and third-line treatment of patients with recurrent cervical cancer. Large scale phase Ⅱ and phase Ⅲ clinical trials demonstrated that bevacizumab-containing chemotherapy was effective in the first- and second-line treatment of patients with persistent cervical cancer, prolonged survival time and improved remission rate. The article also reviews the research progress on predictive factors of bevacizumab efficacy, showing the use of imaging and biomarkers in predicting the efficacy of bevacizumab treatment. In addition, this article analyzes the cost-effectiveness of bevacizumab, finding that bevacizumab combined with chemotherapy meets the standard of cost-effectiveness.
