Evaluation of tear film and meibomian gland function in dry eye patients using Keratograph 5M.
- Author:
Kexuan ZHU
1
;
Wenjia XIE
1
;
Jinglu YING
1
;
Yufeng YAO
2
Author Information
1. Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
2. Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China. yaoyf@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Corneal Topography;
instrumentation;
Diagnostic Equipment;
Dry Eye Syndromes;
diagnostic imaging;
Female;
Humans;
Male;
Meibomian Glands;
diagnostic imaging;
Tears;
diagnostic imaging
- From:
Journal of Zhejiang University. Medical sciences
2016;45(4):422-428
- CountryChina
- Language:Chinese
-
Abstract:
To assess the application of Keratograph 5M in evaluating tear film and meibomian gland function in patients with dry eye.A total of 144 eyes were recruited in the study, in which 72 eyes were from patients diagnosed with dry eye and 72 eyes were from healthy subjects. All subjects finished following tests or examinations:ocular surface disease index (OSDI) to evaluate eye symptoms; Keratograph 5M examination to obtain tear meniscus height (TMH), noninvasive tear break-up time (NIBUT) including first NIBUT (NIBUT-Fir) and average NIBUT (NIBUT-Ave), and infrared meibography; and fluorescein sodium staining to obtain fluorescein tearbreak-up time (FBUT).Dry eye group had higher OSDI score than healthy control group, but its TMH, NIBUT-Fir and NIBUT-Ave were lower than those in healthy control group (all<0.01). Total meiboscore in dry eye group was higher than that in healthy control group (<0.01), and it showed a significant correlation with NIBUT-Fir and NIBUT-Ave (=-0.449 and -0.398,<0.01), but no correlation with ages was observed (=0.031,>0.05). The NIBUT-Fir and NIBUT-Ave showed a significant correlation with FBUT (=0.833 and 0.727,<0.01).Keratograph 5M is a convenient, accurate and non-invasive method to assess the function of tear film and meibomian gland, and the new meibography scoring system can evaluate the function of meibomian gland objectively and succinctly.
