Reasearch progress on the role of neutrophils in asthma.
- Author:
Tingting LI
1
;
Yuehai KE
1
;
Hongqiang CHENG
2
Author Information
1. Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
2. Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China. hqcheng11@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Asthma;
physiopathology;
therapy;
Cytokines;
Humans;
Inflammation;
physiopathology;
therapy;
Neutrophils;
immunology;
physiology;
Th1 Cells;
Th17 Cells
- From:
Journal of Zhejiang University. Medical sciences
2016;45(5):544-549
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a phenotypically heterogeneous chronic disease of the airways. Studies have found that neutrophils are crucial to airway inflammation in acute asthma, persistent asthma, particularly in asthma of poor response to glucocorticoid treatment. The role of neutrophils in development of bronchial asthma is complex, as they can release a potent source of cytokines and inflammatory mediators participating in asthma. Differing from eosinophilic inflammatory asthma, neutrophilic inflammatory asthma is not depend on helper T (Th)2 cells, but may be related to Th1 and Th17 cells. This review highlights the role of neutrophils in the development of asthma, and the treatment of neutrophilic asthma with biological agents and novel small molecules.
