Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population.
- Author:
Bo GONG
1
;
Xiulan LI
;
Ning LI
;
Fang HAO
;
Rong CHEN
;
Guangqun ZENG
;
Dingding ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Amino Acid Oxidoreductases; genetics; Asian Continental Ancestry Group; genetics; Glaucoma, Open-Angle; genetics; Humans; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2015;32(1):89-93
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate association between the lysyl oxidase-like 1 (LOXL1) gene single nucleotide polymorphism (SNP) and primary open-angle glaucoma (POAG) in Sichuan population.
METHODSIn this study,416 subjects with primary open-angle glaucoma and 997 normal controls were recruited.Three reported LOXL1 tag SNPs (rs1048661,rs3825942 and rs2165241) were genotyped by SNaPshot method.
RESULTSThe study showed that the genotypes of LOXL1 rs1048661,rs3825942 and rs2165241 between POAG and control groups were not statistically significant (OR=1.085, 95%CI 0.92-1.28, P=0.578 for rs1048661; OR=1.059, 95%CI 0.82-1.37, P=0.846 for rs3825942; OR=1.006, 95%CI 0.77-1.32, P=0.966 for rs2165241, respectively). There were no significant difference in allele frequency distribution of LOXL1 rs1048661、rs3825942 and rs2165241 between POAG and normal controls (P=0.322, P=0.660, P=0.965).
CONCLUSIONThe results from the present study do not indicate the association of LOXL1 SNPs (rs1048661, rs3825942 and rs2165241) with POAG in Sichuan population.
