Advance in research on the association of ALDH2 gene polymorphisms with cancer susceptibility in drinkers.
10.3760/cma.j.issn.1003-9406.2015.01.025
- VernacularTitle:ALDH2基因rs671多态性与饮酒人群肿瘤易感性之间相关性的研究进展
- Author:
Chuanping CHEN
1
;
Luping LI
Author Information
1. Department of Clinical Laboratory, the Sixth People's Hospital of Shenyang, Shenyang, Liaoning 110006, P. R. China. Email: luping4758@163.com.
- Publication Type:Journal Article
- MeSH:
Alcohol Drinking;
genetics;
Aldehyde Dehydrogenase;
genetics;
Aldehyde Dehydrogenase, Mitochondrial;
Genetic Predisposition to Disease;
Humans;
Neoplasms;
etiology;
genetics;
Polymorphism, Genetic
- From:
Chinese Journal of Medical Genetics
2015;32(1):113-116
- CountryChina
- Language:Chinese
-
Abstract:
Aldehyde dehydrogenase 2 (ALDH2), as one of the most important alcohol metabolizing enzymes, plays a significant role in the detoxification process of acetaldehyde which is a main carcinogenic product of alcoholic metabolism. Alteration in its genotypes (particularly at the site of rs671) is closely associated with a variety of tumors in drinkers. Recent advance in the research of the association of the ALDH2 gene rs671 polymorphisms with cancer susceptibility in drinkers is reviewed.
