Detection of chromosomal aneuploidies in spontaneous abortion samples by fluorescence in situ hybridization.
- Author:
Ping WEI
1
;
Yunxing LI
;
Chun CHEN
;
Lan ZENG
;
Shengfang QIN
;
Xueyan WANG
;
Na XI
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Spontaneous; diagnosis; genetics; Adult; Aneuploidy; Chromosome Aberrations; Chromosomes, Mammalian; genetics; Female; Fetal Diseases; diagnosis; genetics; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Pregnancy; Prenatal Diagnosis; Young Adult
- From: Chinese Journal of Medical Genetics 2015;32(2):229-232
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze 81 spontaneous abortion samples with fluorescence in situ hybridization (FISH).
METHODSChromosome 13, 21, 16, 22, 18, X and Y probes were used to detect the samples.
RESULTSFISH was successful in 80 cases (98.77%). Among these, 35 (43.75%) had an abnormal karyotype, which included 19 autosomal aneuploidies, 6 sex chromosome aneuploidies, 9 triploidies and 1 tetraploidy.
CONCLUSIONFISH is a rapid and easy method for detecting chromosomal aneuploidies in spontaneous abortion samples, and has a higher detection rate in early spontaneous abortion samples.
