Association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation in ethnic Uygurs and Hans from Xinjiang.
- VernacularTitle:VKORC1基因-1639G/A多态性与新疆地区维吾尔族、汉族心房颤动的相关性研究
- Author:
Peisong WU
1
;
Siqi MENG
;
Xianhui ZHOU
;
Guojun XU
;
Jinxin LI
;
Yu ZHANG
;
Ling SUN
;
Qiang XING
;
Shuai SUN
;
Hongli WANG
;
Qina ZHOU
;
Baopeng TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; ethnology; genetics; Atrial Fibrillation; ethnology; genetics; Base Sequence; China; ethnology; Female; Humans; Male; Middle Aged; Molecular Sequence Data; Polymorphism, Single Nucleotide; Vitamin K Epoxide Reductases; genetics
- From: Chinese Journal of Medical Genetics 2015;32(2):264-268
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation (AF) in ethnic Uygurs and Hans from Xinjiang.
METHODSThe above polymorphism was detected among 100 Uygur and 102 Han AF patients and 103 Uygur and 111 Han subjects that have no AF with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
RESULTSA statistically significant difference was detected between the patient and control groups of Uygur origin in terms of genotypic and allelic frequencies (P<0.05). Logistic regression analysis also indicated the -1639G/A polymorphism as an independent risk factor for AF in Uygur population (OR=2.085, 95% CI: 1.067-4.072, P=0.031). No similar statistical difference was found between the patient and control groups of Han origin (P>0.05).
CONCLUSIONThe -1639G/A polymorphism of VKORC1 gene is associated with AF in the Uygur population but not in Hans.
