Notch signaling in bone formation and related skeletal diseases.
10.3760/cma.j.issn.1003-9406.2015.02.027
- Author:
Hongwei MA
1
;
Yaqiong WU
;
Haifeng ZHANG
Author Information
1. Center of Experiment Medicine, School of Basic Medical Science, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China. hfzhang@fmmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Bone Development;
Bone Diseases;
genetics;
metabolism;
Bone and Bones;
metabolism;
Humans;
Osteoblasts;
cytology;
metabolism;
Osteogenesis;
Receptors, Notch;
genetics;
metabolism;
Signal Transduction
- From:
Chinese Journal of Medical Genetics
2015;32(2):274-279
- CountryChina
- Language:Chinese
-
Abstract:
Notch signaling is highly conserved in evolution and regarded as a key factor in cell fate determination. It mediates cell-to-cell interactions that are critical for embryonic development and tissue renewal, and is involved in the occurrence and metastasis of neoplasm. Recent researches have found that such signaling plays an important role in modulating the differentiation of chondrocytes, osteoblasts and osteoclasts. Dysfunction of Notch signaling can result in many skeletal diseases such as bone tumor, disorders of bone development or bone metabolism.
