Multifocal Inflammatory Leukoencephalopathy: Use of Thallium-201 SPECT and Proton MRS.
10.3346/jkms.2003.18.4.621
- Author:
Yang Ha HWANG
1
;
Chung Kyu SUH
;
Sung Pa PARK
Author Information
1. Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea. sppark@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Leukoencephalopathy;
Fluorouracil;
Levamisole;
Magnetic Resonance Spectroscopy;
Tomography;
Emission Computed;
Singl-Photon
- MeSH:
Adjuvants, Immunologic/adverse effects/therapeutic use;
Antimetabolites, Antineoplastic/adverse effects/therapeutic use;
Aspartic Acid/*analogs & derivatives/metabolism;
Axons/pathology;
Biopsy;
Brain/pathology;
Brain Neoplasms/secondary;
Choline/metabolism;
Colorectal Neoplasms/drug therapy/pathology;
Diagnosis, Differential;
Fluorouracil/adverse effects/therapeutic use;
Human;
Lactic Acid/metabolism;
Leukoencephalopathy, Progressive Multifocal/*diagnosis/etiology;
Levamisole/adverse effects/therapeutic use;
Magnetic Resonance Spectroscopy/*methods;
Male;
Middle Aged;
Neoplasm Metastasis;
Thallium Radioisotopes/*diagnostic use;
Tomography, Emission-Computed, Single-Photon/*methods
- From:Journal of Korean Medical Science
2003;18(4):621-624
- CountryRepublic of Korea
- Language:English
-
Abstract:
In a patient receiving 5-fluorouracil and levamisole, neurologic deficits suggest the cerebral demyelinating syndrome as a differential diagnosis. The authors report a patient diagnosed as multifocal inflammatory leukoencephalopathy for which thallium-201 ((201)Tl) single photon emission computed tomography (SPECT) and proton magnetic resonance spectroscopy (MRS) were employed as noninvasive diagnostic tools. (201)Tl SPECT study was negative and proton MRS showed an increase of choline and lactate and well preserved N-acetylaspartate. These findings support histopathologic findings of multifocal inflammatory leukoencephalopathy revealing demyelination with relative axonal sparing in the patient.
