Screening of specific miRNA in early gastric cancer.
- Author:
Jing HAN
1
;
Jiangliu YU
;
Zhiqiang LING
Author Information
- Publication Type:Journal Article
- MeSH: Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; genetics; Oligonucleotide Array Sequence Analysis; Stomach Neoplasms; genetics; Up-Regulation
- From: Chinese Journal of Gastrointestinal Surgery 2014;17(2):175-179
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the micro-RNA (mirna) expression profile in tissues of early gastric cancer and to screen the specific mirna associated with gastric cancer.
METHODSGene chip technology was used to detect the expression of mirna in early gastric cancer tissues and adjacent normal tissues.
RESULTSCompared to adjacent normal tissues, a total of 36 mirnas were down-regulated, such as mir-9-1, mir-103 and mir-141, while 12 mirnas were up-regulated, such as mir-196a, mir-142-3p and mir-25, etc.
CONCLUSIONAbnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer.
