Role of molecular subtypes in gastrointestinal stromal tumors in a clinical setting.
- Author:
Zhizhong PAN
1
;
Xiaojun WU
;
Wu JIANG
Author Information
1. Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangdong 510060, China. panzhzh@sysucc.org.cn.
- Publication Type:Journal Article
- MeSH:
Gastrointestinal Neoplasms;
genetics;
therapy;
Gastrointestinal Stromal Tumors;
genetics;
therapy;
Genotype;
Humans;
Prognosis;
Proto-Oncogene Proteins c-kit
- From:
Chinese Journal of Gastrointestinal Surgery
2014;17(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal stromal tumors(GIST) are known for their molecular alterations in KIT or PDGFR genes, and have become the paradigm of molecularly targeted therapies for solid tumors. Recent researches of genotype and phenotype demonstrate that molecular subtypes can predict the response to treatment with tyrosine kinase inhibitors and are related with prognosis. Different strategies will be recommended according to different molecular subtypes of GIST in the future for treatment optimization and individualization.
