Evaluation of effective doses of hepatitis B immunoglobulin to eliminate hepatitis B surface antigen from infected neonates.
- Author:
Ping ZHANG
1
;
Wei LU
;
Shun-tian LI
;
Wei YOU
;
Yu-rong ZHANG
;
Jing CHEN
Author Information
- Publication Type:Journal Article
- MeSH: DNA, Viral; Dose-Response Relationship, Immunologic; Female; Hepatitis B; prevention & control; therapy; Hepatitis B Surface Antigens; blood; immunology; Hepatitis B virus; genetics; immunology; Humans; Immunoglobulins; administration & dosage; therapeutic use; Infant, Newborn; Infectious Disease Transmission, Vertical; prevention & control
- From: Chinese Journal of Hepatology 2012;20(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the effective dose of hepatitis B immunoglobulin (HBIG) for clearing maternally-transmitted hepatitis B virus (HBV) from a newborn.
METHODSFull-term neonates born to HBV-infected mothers were tested for hepatitis B surface antigen (HBsAg) and HBV DNA in venous blood, Individuals with positive results within two hours after birth were selected for study, and divided among two treatment groups: research group receiving HBIG continually adjusted to quantitative levels of neonatal HBsAg and HBV DNA levels; control group receiving standard HBIG 200IU dose. All neonates were also treated with 10 micrograms of recombinant vaccine. The decreases in HBsAg and HBV DNA over 12 months were comparatively analyzed between the two treatment groups.
RESULTSThe two treatment groups (HBIG adjusted vs. standard) were statistically similar in Apgar score (9.38+/-0.49 vs. 9.37+/-0.48), neonate body weight (3458.67+/-374.93 vs. 3558.61+/-322.85 g), maternal age (26.33+/-3.63 vs. 25.33+/-3.03), and initial HBsAg and HBV DNA levels (rank sum test Z = 1.381, and Z = 0.700, respectively) (all, P more than 0.05). Successful clearance of HBV infection within 12 months was achieved in significantly more neonates in the HBIG adjusted therapy group than in the standard therapy group (82.8% vs. 57.4%; x2 = 9.696, P less than 0.05).
CONCLUSIONAdjusting the neonatal HBIG dose according to HBsAg and HBV DNA levels can improve the success rate of clearing maternally-transmitted HBV.
