Association of pro-B-type natriuretic peptide levels with heart rate variability in diabetic patients.
- Author:
Hui LIN
1
;
Xiao-Huan CHEN
;
Zhi-Hua WU
;
Dong-Hui ZHANG
;
Xiao-Yan CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Diabetes Mellitus; metabolism; physiopathology; Heart Rate; Humans; Natriuretic Peptide, Brain; metabolism; Peptide Fragments; metabolism
- From: Journal of Southern Medical University 2015;35(1):146-148
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between pro-B-type natriuretic peptide (NT-proBNP) and heart rate variability (HRV) in patients with diabetes.
METHODSHRV and NT-proBNP levels were assessed in 58 patients with diabetes.The time domain and frequency domain indices and the level of NT-proBNP were compared between patients with normal and abnormal HRV, and the correlation of HRV index and NT-proBNP was analyzed.
RESULTSThe NT-proBNP level was significantly higher in patients with abnormal HRV than in those with normal HRV (320.2±88.3 vs 80.4±25.2 pg/ml, P<0.01).The level of NT-proBNP was negatively correlated with SDNN (r=-0.55, P<0.05), triangle index (r=-0.52, P<0.05), LF (r=-0.62, P<0.01), and VLF (r=-0.56, P<0.05).
CONCLUSIONNT-proBNP level is correlated with HRV, and an increased NT-proBNP indicates cardiac autonomic neuropathy in diabetic patients.
