3T magnetic resonance T2 mapping for evaluation of cartilage repair after matrix-associated autologous chondrocyte transplantation.
- Author:
Jun ZHANG
1
;
Xian XU
;
Xue LI
;
Min CHEN
;
Tian-Ming DONG
;
Pan-Li ZUO
;
Ning-Yu AN
Author Information
- Publication Type:Journal Article
- MeSH: Cartilage, Articular; pathology; Chondrocytes; transplantation; Humans; Magnetic Resonance Imaging; Transplantation, Autologous
- From: Journal of Southern Medical University 2015;35(1):141-145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the value of magnetic resonance imaging (MRI) T2 mapping in quantitative evaluation of cartilage repair following matrix-associated autologous chondrocyte transplantation (MACT).
METHODSSix patients (with 9 plug cartilages) following MACT underwent MRI on a 3.0 Tesla MR scan system at 3, 6 and 12 months after the surgery. The full-thickness and zonal areas (deep and superficial layers) T2 values were calculated for the repaired cartilage and control cartilage.
RESULTSThe mean T2 values of the repaired cartilage after MACT were significantly higher than that of the control cartilages at 3 and 6 months (P<0.05), but not at 12 months (P=0.063). At 6 and 12 months, the T2 values of the superficial layers were significantly higher than those of the deep layers in the repaired cartilages (P<0.05). The zonal (deep and superficial layers) T2 values of the repaired cartilages decreased significantly over time at 6 and 12 months as compared to those at 3 months after the surgery (P<0.05).
CONCLUSIONMRI T2 mapping can serve as an important modality for assessing the repair of the articular cartilage following MACT.
