Association of single nucleotide polymorphisms in the promoter of GABAA receptor β2 subunit gene with schizophrenia.
- Author:
Lin ZHOU
1
;
Lu ZONG
;
Lulu ZHANG
;
Cong DENG
;
Cunyou ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Case-Control Studies; Ethnic Groups; Heterozygote; Humans; Male; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, GABA-A; genetics; Schizophrenia; genetics
- From: Journal of Southern Medical University 2015;35(2):256-259
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the genetic association between schizophrenia and the polymorphism of GABA(A) receptor β2 subunit (GABRB2) gene.
METHODSA population association analysis was performed of 5 single nucleotide polymorphisms (SNPs) in the proximal promoter of GABRB2 gene by PCR and sequencing of the genomic DNA in a cohort of 172 schizophrenics and 167 controls of Chinese Han nationality.
RESULTSOne out of the 5 SNPs, namely rs3811996, was found to be significantly associated with schizophrenia especially in the male cohorts, where the heterozygous genotypes (A/G) and minor allele G displayed lower frequencies in case group than in the controls.
CONCLUSIONWe found a new risk, SNP rs3811996, for paranoia schizophrenia, which further supports the importance of genetic variations of GABRB2 in the etiology of schizophrenia.
