Failed fertilization after ICSI: causes and countermeasures.
- Author:
Dan CHENG
1
;
Jie LI
;
Cui-Cui GUO
;
Cheng-Liang XIONG
Author Information
1. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. chengdanny@126.com
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Male;
Oocytes;
Sperm Injections, Intracytoplasmic;
Spermatozoa;
Treatment Failure
- From:
National Journal of Andrology
2011;17(12):1131-1134
- CountryChina
- Language:Chinese
-
Abstract:
As a new technique for IVF, ICSI has a high rate of monospermy but cannot prevent all fertilization failures, of which the possible causes are poor oocytes or sperm, abnormal oocyte activation, and ICSI technical problems. Controlled ovarian hyperstimulation during IVF could increase the apoptosis of oocytes and subsequently induce fertilization failure. There are several methods for artificial activation in case of oocyte activation failure. Sperm-induced fertilization failure is mostly due to minute malformation of sperm, for which morphologically selective ICSI is generally employed. However, totally failed fertilization after ICSI remains a real challenge.
