Relationship of sperm morphology with reproductive hormone levels in infertile men.
- Author:
Wen-Hao TANG
1
;
Hui JIANG
;
Lu-Lin MA
;
Kai HONG
;
Qun ZHONG
;
Chi-Sun YANG
;
Lian-Ming ZHAO
;
De-Feng LIU
;
Jia-Ming MAO
;
Yi YANG
;
Qian CHEN
;
Ren-Pei YUAN
;
Xin ZHANG
;
Bin LI
;
Nan WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Estradiol; blood; Follicle Stimulating Hormone; blood; Humans; Infertility, Male; blood; physiopathology; Luteinizing Hormone; blood; Male; Prolactin; blood; Semen; Semen Analysis; Sex Hormone-Binding Globulin; metabolism; Sperm Count; Spermatozoa; abnormalities; Testis; Testosterone; blood
- From: National Journal of Andrology 2012;18(3):243-247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of sperm morphology with reproductive hormones in infertile men and the pathogenesis of teratozoospermia.
METHODSThis study included 90 infertile men aged 25 - 40 years. We measured their testis volumes using the Prader orchidometer, conducted routine semen analyses according to the WHO laboratory standard, and determined the concentrations of reproductive hormones and sex hormone-binding globulin (SHBG) by chemiluminescence and the levels of free testosterone (FT) and bioavailable testosterone (BioT).
RESULTSAll the subjects showed normal sperm concentration. Based on the results of semen morphology analysis, the 90 infertile men were equally divided into groups 1 (morphologically normal sperm <4%), 2 (morphologically normal sperm > or = 4% and <10%), and 3 (morphologically normal sperm > or = 10%), with no significant differences in age among the three groups (P>0.05). The volumes of the left testis were (14.27 +/- 3.65) ml, (16.90 +/- 3.57) ml and (14.57 +/- 3.57) ml, respectively (P = 0.006 group 1 vs group 2, P = 0.741 group 1 vs group 3, P = 0.014 group 2 vs group 3), and those of the right testis were (14.60 +/- 3.70) ml, (16.60 +/- 3.35) ml and (14.67 +/- 3.54) ml, respectively (P = 0.050). There were no significant differences among the three groups in prolactin, follicle-stimulating hormone, luteinising hormone, estradiol, total testosterone and SHBG, (P>0.05). The levels of serum FT were (0.25 +/- 0.07) nmol/L, (0.29 +/- 0.07) nmol/L and (0.31 +/- 0.13) nmol/L (P = 0.086 group 1 vs group 2, P= 0.010 group 1 vs group 3, P= 0.364 group 2 vs group 3), and those of BioT were (5.81 +/- 1.58) nmol/L, (6.78 +/- 1.55) nmol/L and (7.29 +/- 3.02) nmol/L, respectively (P = 0.086 group 1 vs group 2, P = 0.010 group 1 vs group 3, P = 0.364 group 2 vs group 3). The percentage of morphologically normal sperm was positively correlated with the levels of serum FT and BioT (P<0.05).
CONCLUSIONThe higher the levels of serum FT and BioT, the higher the percentage of morphologically normal sperm, which suggests that serum FT and BioT might be involved in the pathogenesis of teratozoospermia.
