Analysis of survival and prognosis in 409 newly diagnosed patients with diffuse large B-cell lymphoma.
- Author:
Jingjing WEN
1
;
Jiali ZHOU
1
;
Zhibin LIU
1
;
Ting LIU
1
;
Caigang XU
1
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Disease-Free Survival; Female; Humans; Lymphoma, Large B-Cell, Diffuse; drug therapy; pathology; Male; Middle Aged; Multivariate Analysis; Prognosis; Young Adult
- From: Chinese Journal of Hematology 2014;35(4):318-324
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo Explore the poor prognostic factors of diffuse large B-cell lymphoma (DLBCL).
METHODSThe clinical data of 409 newly diagnosed patients with DLBCL from January 2000 to December 2010 were collected, and the prognostic factors by univariate and multivariate stratification were analyzed .
RESULTSOf the 409 DLBCL patients, 244 were males and 165 females, the median age was 56(16-89) years old, the median follow-up time was 23(2-108) months. In univariate analysis, age, clinical stage, B symptoms, ECOG scores, the international prognostic index (IPI) scores, bone marrow involvement, low absolute lymphocyte count (ALC), high LDH, β2-MG>2 times of normal, regimen and therapeutic effect had significant influence on OS and PFS (P<0.05). Multivariate analysis showed that stage III-IV and high LDH were the poor prognostic factors of OS and PFS (P<0.05). When IPI scores were included, low ALC and IPI 3-5 scores were the poor predictors of OS and PFS in CHOP-like group (232 cases), revised IPI (R-IPI) was an independent poor predictors of OS and PFS in RCHOP-like group (177 cases).
CONCLUSIONStage III-IV and high LDH have negative influence on OS and PFS in patients with DLBCL, low ALC and IPI 3-5 scores affect OS and PFS in CHOP-like group, R-IPI affects OS and PFS in RCHOP-like group.
