Expression of Th17 Cytokines in Skin Lesions of Patients with Psoriasis
- Author:
Jiawen LI
1
;
Xu'e CHEN
;
Zhixiang LIU
;
Qing YUE
;
Houjun LIU
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
psoriasis;
Th17;
IL-17;
IL-23 (p19/p40);
IL-6
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2007;27(3):330-332
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the role of Th17 cytokines in the pathogenesis of psoriasis, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of IL-17, IL-23 (p19/p40), and IL-6 in skin lesions and non-lesions of the patients with psoriasis and skin tissues of normal subjects. The results showed that the mRNA expression levels of IL-17, IL-23p19, IL-23p40 and IL-6 in psoriasis leision were significantly higher than those of non-leisions (1.231±0.843 vs 1.003±0.044, 1.166±0.142 vs 0.765±0.133, 1.125±0.104 vs 0.730±0.103, 1.186±0.222 vs 0.976±0.122, respectively, all P＜0.05). Meanwhile, The expression levels of IL-17 mRNA,IL-23p19 mRNA, IL-23p40 mRNA and IL-6 mRNA were higher in non-leisions than those in normal skin tissues (1.003±0.044 vs 0.620±0.104, 0.765±0.133 vs 0.584±0.078, 0.730±0.103 vs 0.000±0.000, 0.976±0.122 vs 0.656±0.121, respectively, all P＜0.05). The overexpression of Th17 cytokines in the skin lesions of patients with psoriasis may indicate that Th17 cytokines play a very important role in the immunopathogenesis of psoriasis.
