Modulation of Interleukin-15-induced Suppression of Human Neutrophil Apoptosis by TNFα
- Author:
Xiuping LIU
1
;
Changyun XIONG
;
Chunhong LI
;
Deguang YANG
Author Information
1. Huazhong Universty of Science and Technology
- Keywords:
neutrophil;
interleukin-15;
TNFα;
apoptosis;
Bcl-Xl
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2007;27(4):354-357
- CountryChina
- Language:Chinese
-
Abstract:
Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFα was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFα was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFα might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFα can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.
