Effect of Excessive Iodine on Immune Function of Lymphocytes and Intervention with Selenium
- Author:
Xiaoyi CHEN
1
;
Liegang LIU
;
Ping YAO
;
Dong YU
;
Liping HAO
;
Xiufa SUN
Author Information
1. 华中科技大学同济医学院
- Keywords:
excessive iodine;
lymphocyte;
immune function;
intervention
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2007;27(4):422-425
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the effect of excessive iodine on immune function of lymphocytes and the role of selenium supplementation with excessive iodine intake, the changes of T lymphocyte number, ratio of subsets, activity of natural killer (NK) cells and lymphocytes proliferation response were investigated. 150 female BALB/C mice were randomly divided into 5 groups in terms of their body weight (n=30 in each group), and 10 of each group were taken as one batch for test. Mice in the 5 groups were orally administrated with iodine 0 (group Ⅰ ), 1500 (group Ⅱ), 3000 (group Ⅲ),6000 μg/L (group Ⅳ), iodine 6000 μg/L plus selenium 0.3 mg/L (group Ⅴ) respectively for 30 days.Lymphocyte proliferation response, CD4+/CD8+, Th1/Th2 and the activity of NK cells were measured. CD4+/CD8+ was significantly lower, while lymphocyte proliferation response stronger, and Th1/Th2 and the activity of NK cells significantly higher in group Ⅳ than in group Ⅰ (P＜0.01).There was no significant difference in all indexes between group Ⅴ and group Ⅰ (P＞0.05). It was suggested that excessive iodine as exogenous chemical materials can induce disorders of T lymphocyte immune function in mice. 0.3 mg/L selenium supplementation can protect mice against toxicity induced by 6000 μg/L iodine.
