Association of G+1688A Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 Gene with Myocardial Infarction in the Chinese Han Population
- Author:
Ying YANG
1
;
Longxian CHENG
;
Nsenga RIPEN
;
Meian HE
;
Zhitang CHANG
;
Tangchun WU
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
platelet endothelial adhesion molecule-1;
single nucleotide polymorphism;
myocardial infarction;
polymerase chain.reaction-restriction fragment-length polymorphism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2007;27(5):520-523
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the association of G+1688A (Ser563Asn) polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene with myocardial infarction (MI) in the Chi- nese Han population, the G+1688A polymorphism in PECAM-1 gene was detected by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) method among 502 subjects, including 218 patients with MI and 284 controls. The results showed that there was significant dif-ference in AA frequencies of genotype G+1688A polymorphism between case and control groups (39% vs 24%, P<0.001). A similar trend was observed on the allele frequencies (A/G: 62% vs 49%, P<0.001). Among the subjects with high serum total cholesterol level or high systolic blood pressure level, the variant AA genotype was associated with high risk of MI (adjusted OR, 2.13; 95% CI, 1.08-4.41 and adjusted OR, 2.53; 95%CI, 1.63-3.63). The single nucleotide polymorphism (SNP) at position +1688 in the exon 8 of PECAM-1 gene was associated with MI and the allele A might be a risk factor for MI in the Chinese Han population.
