Effect of stability and dissolution of realgar nano-particles using solid dispersion technology.
- Author:
Teng GUO
1
;
Feng SHI
2
;
Gang YANG
2
;
Nian-Ping FENG
2
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; methods; Drug Carriers; chemistry; Drug Stability; Drugs, Chinese Herbal; chemistry; Nanoparticles; chemistry; Poloxamer; chemistry; Polyethylene Glycols; chemistry; Solubility
- From: China Journal of Chinese Materia Medica 2013;38(17):2782-2787
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo improve the stability and dissolution of realgar nano-particles by solid dispersion.
METHODUsing polyethylene glycol 6000 and poloxamer-188 as carriers, the solid dispersions were prepare by melting method. XRD, microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As(2)0(3) were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions.
RESULTThe results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly, the reunion of realgar nano-particles and content of As(2)0(3) were reduced for the formation of solid dispersions.
CONCLUSIONThe solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability, dissolution and solubility.
