Advances in studies on 3-hydroxy-3-metllylglutaryl coenzyme A reductase in terpenoids biosynthesis of medicinal plants.
- Author:
Yu-Jia LIU
1
;
Xia-Nan ZHANG
2
;
Qi-Qing CHENG
2
;
Lu-Qi HUANG
3
;
Wei GAO
2
Author Information
1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. lyjlife@sina.com
2. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
3. National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
- Publication Type:Journal Article
- MeSH:
Hydroxymethylglutaryl CoA Reductases;
metabolism;
Plants, Medicinal;
enzymology;
Terpenes;
metabolism
- From:
China Journal of Chinese Materia Medica
2013;38(19):3226-3233
- CountryChina
- Language:Chinese
-
Abstract:
There exists many kinds and a huge number of terpenoid in medicinal plants, which show a wide range of pharmacological activities. 3-Hydroxy-3-metllylglutaryl coenzyme A reductase(HMGR) is a key rate-limiting enzyme in terpenoid biosynthetic pathway . HMGR plays an important role in the regulation of secondary metabolism of the terpenoid. The paper summarized the biological function and the catalytic mechanism of HMGR, the cloning and the structure of the gene as well as its research progress in some medicinal plants.
