Analysis on preparation and characterization of asiaticoside-loaded flexible nanoliposomes.
- Author:
Yan REN
1
;
Xing-Dong HE
2
;
Bei-Cheng SHANG
2
;
Xiu-Kun BAO
3
;
Yan-Fang WANG
3
;
Ji-Sheng MA
3
Author Information
1. Engineering Research Center of Bioreactor and Pharmaceutical Development under Ministry of Education, Jilin Agricultural University, Changchun 130118, China. 9877699@qq.com
2. Suzhou Sciscape Biomed Scitech Co., Ltd., Suzhou 215125, China.
3. Engineering Research Center of Bioreactor and Pharmaceutical Development under Ministry of Education, Jilin Agricultural University, Changchun 130118, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Liposomes;
chemistry;
Nanoparticles;
chemistry;
Triterpenes;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(19):3282-3286
- CountryChina
- Language:Chinese
-
Abstract:
Asiaticoside is a compound extracted from traditional Chinese medicine Centella asiatica, and mainly used in wound healing and scar repair in clinical, with notable efficacy. However, its poor transdermal absorption and short action time restrict its wide application. In this experiment, the reserve-phase-extrusion-lyophilization method was conducted to prepare the lyophilized asiaticoside-loaded flexible nanoliposomes (LAFL). Its characteristics including electron microscope structure, particle size, Zeta potential, entrapment rate, drug-loading rate, stability and drug release were determined with the intelligent transdermal absorption instrument. LAFL were white spheroids, with pH, particle size and zeta potential of 7. 03, 70. 14 nm and - 36. 5 mV, respectively. The average entrapment rate of the 3 batch samples were 31. 43% , and the average asiaticoside content in 1 mg lyophilized simple was 0. 134 mg. The results indicated that LAFL have good physicochemical properties and pharmaceutical characteristics, with an improved transdermal performance.
