Study on effect of combined application on distribution of gastrodigenin in rats.
- Author:
Qin ZHENG
1
;
Wen-Hai XIONG
2
;
Jia-Yu LIU
2
;
Ya-Qin WANG
2
;
Peng-Yi HU
2
;
Shuang HU
2
;
Xin XUE
2
;
Ming YANG
2
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. zhengqin912006@163.com
2. Key Laboratory of Modern Preparation of Traditional Chinese Medicine under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Benzyl Alcohols;
metabolism;
pharmacokinetics;
Brain;
metabolism;
Chromatography, High Pressure Liquid;
Female;
Gastrodia;
chemistry;
Kidney;
metabolism;
Ligusticum;
chemistry;
Liver;
metabolism;
Lung;
metabolism;
Male;
Rats;
Spleen;
metabolism
- From:
China Journal of Chinese Materia Medica
2013;38(19):3368-3372
- CountryChina
- Language:Chinese
-
Abstract:
To determine the concentration of gastrodigenin in tissue homogenates with high performance liquid chromatography (HPLC) , in order to study the changes of the distribution of gastrodigenin before and after combined application in rat tissues, including heart, liver, spleen, lung, kidney and brain tissues. The study showed that gastrodigenin could be found in kidney, liver, heart, lungs, spleen and brain tissues. After the combined application of Gastrodiae Rhizoma and Ligustici Wallichii Rhizoma, the content of gastrodigenin decreased in kidney and liver to varying degrees, while increasing in lung and brain. This indicated that Ligustici Wallichii Rhizoma had certain impact on the in vivo distribution of gastrodigenin, an active ingredient in Gastrodiae Rhizoma, because it could improve gastrodigenin's distribution in lung and brain tissues. The study provides scientific basis for the combined application of Gastrodiae Rhizoma and Ligustici Wallichii Rhizoma in treating brain diseases.
