Pharmacokinetics of scutellarin and its derivant scutellarin ethyl ester in rats.
- Author:
Li-Wei ZHU
1
;
Xiao-Qian LIU
2
;
Jing FENG
2
;
Hui-Min GAO
2
;
Hong YI
2
;
Zhi-Min WANG
2
;
Qing-Ju MENG
3
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhuliwei7322@163.com
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
3. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Apigenin;
pharmacokinetics;
Chromatography, High Pressure Liquid;
Flavones;
pharmacokinetics;
Glucuronates;
pharmacokinetics;
Glucuronides;
pharmacokinetics;
Male;
Rats;
Rats, Wistar
- From:
China Journal of Chinese Materia Medica
2013;38(19):3373-3377
- CountryChina
- Language:Chinese
-
Abstract:
To develop a HPLC method for determination of the concentration of scutellarin and scutellarin ethyl ester and their pharmacokinetics were also compared. 104 mg kg-1of scutellarin or 114. 5 mg kg-1 scutellarin ethyl ester were given at single dose by oral gavarge. Blood samples were collected from the jugular vein. Plasma concentration was measured by HPLC. The pharmacokinetic parameters were calculated with Winnonlin program. The plasma concentration-time profile of scutellarin and scutellarin ethyl ester were both fitted with non-compartment model and both were double peaks. The main pharmacokinetic parameters of scutellarin and scutellarin ethyl ester were as follows: Tmax Cmax and AUC0-t for scutellarin were (6 +/- 1.26) h, (321.55 +/-48.31) microg L-1 and (2 974 +/-753) h micro.g L-1; for scutellarin ethyl ester, Tmax, Cmax and AUC0-t were 0.5 h, (1 550.82 +/-219.75) +/- microg L- and (6 407 +/- 399) h microg L-1. The speed ingested into the blood of scutellarin ethyl ester was faster than scutellarin, and the bioavailability of scutellarin ethyl ester was two times higher than scutellarin.
