Analysis of clinical effects of parenterally administered shenqi fuzheng on renal function.
- Author:
Yuan-Yuan LI
1
;
Min ZHAO
2
;
Yan-Ming XIE
3
;
Lin LI
4
;
Li YOU
4
Author Information
1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. chibjyy@163.com
2. Guangdong Hospital of Chinese Medicine, Guanzhou 510120, China.
3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
4. School of Statistics, Renmin University of China, Beijing 100872, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Case-Control Studies;
Drug Hypersensitivity;
etiology;
physiopathology;
Drugs, Chinese Herbal;
administration & dosage;
adverse effects;
Female;
Hospital Information Systems;
statistics & numerical data;
Humans;
Kidney;
drug effects;
physiopathology;
Kidney Function Tests;
Male;
Middle Aged;
Pragmatic Clinical Trials as Topic;
Young Adult
- From:
China Journal of Chinese Materia Medica
2013;38(18):3031-3038
- CountryChina
- Language:Chinese
-
Abstract:
This study analyzes the clinical effects of parenterally administered Shenqi Fuzheng on renal function. 20 national, general hospitals were selected. Their hospital information system (HIS) data on 51 898 cases of parenterally administered Shenqi Fuzheng were mined for data. Patients ranged from 18 to 80 years old. 27 718 cases were selected for analysis. Serum creatinine (Scr) and blood urea nitrogen (BUN) levels were taken before and after treatment for outcome evaluation. According to instructions, we divided 197 cases into the treatment group (doses > 250 mL) and 5 728 cases acted as the control group (dose < or = 250 mL). Stratified analysis adjusted for age, sex, hospital illness, treatment, etc. According to the four variables, the case group compared with the control group did not show abnormal renal function changes; 57 confounding factors were balanced using propensity score method resulting in the treatment group showing no abnormal changes in renal function. This HIS b data analysis found that parenterally administered Shenqi Fuzheng above the recommended dosage did not significantly impact on renal function was no significant difference. Prospective studies should be carried out to validate this data.
