Autoantibodies against alpha1 adrenergic receptor related with cardiac remodeling in hypertensive patients by clinical observation.
- Author:
Zheng-zai LI
1
;
Yu-hua LIAO
;
Zi-hua ZHOU
;
Yu-miao WEI
;
Min WANG
;
Feng ZHU
;
Ming CHEN
;
Xiong-bing DU
;
Yan-xiang SUN
;
Hai-yan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Autoantibodies; blood; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypertension; immunology; physiopathology; Logistic Models; Male; Middle Aged; Receptors, Adrenergic, alpha-1; immunology; Ventricular Remodeling; immunology
- From: Chinese Journal of Cardiology 2006;34(7):602-604
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of autoantibodies against alpha(-) adrenergic receptor on cardiac remodeling in patients with hypertension.
METHODSFive hundred and fifty three patients with hypertension in our hospital were selected. The autoantibodies against alpha(1) adrenergic receptor in sera of donor were detected by ELISA, and the results of echocardiography were recorded. By multiple logistic regressions, the risk factors were analyzed on left ventricular enlargement of hypertension.
RESULTSThe percentage of autoantibodies against alpha(1) adrenergic receptor positive was 32.3% (179/553). There were significant difference between the positive group and negative group on the ratio of left atrial enlargement (53.6%, 44.3%, respectively; P < 0.05) and left ventricular enlargement (12.8%, 6.1%, respectively; P < 0.01). The result of regression analysis demonstrated that 4 risk factors were related to left ventricular enlargement, including male, course of disease, heart rate (HR) and autoantibodies against alpha(1) adrenergic receptor in the serum (all P < 0.05).
CONCLUSIONSThe autoantibodies against alpha(1) adrenergic receptor have a relationship with left ventricular enlargement of hypertension. Patients with the activity of autoantibodies against alpha(1) adrenergic might contribute to predict cardiac remodeling.
