Beneficial effects of probucol on endothelial function in patients with acute coronary syndrome.
- Author:
Hong-mei DONG
1
;
Lan HUANG
;
Shan-jun ZHU
;
Zhao-hua GENG
;
Xiao-jing WU
;
Jun JIN
;
Xue-jun YU
;
Jun QIN
;
Hong-mei XIA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angina, Unstable; blood; drug therapy; Anticholesteremic Agents; therapeutic use; Endothelial Cells; drug effects; physiology; Endothelium, Vascular; drug effects; physiopathology; Female; Humans; Lipoproteins, LDL; blood; Male; Middle Aged; Myocardial Infarction; drug therapy; physiopathology; Nitric Oxide; blood; Probucol; therapeutic use
- From: Chinese Journal of Cardiology 2006;34(7):609-612
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe study investigate the antioxidant probucol on endothelial function in patients with acute coronary syndrome (ACS).
METHODSA total of 49 ACS patients randomly received standard therapy plus probucol (P, n = 24) or standard therapy (C, n = 25). Plasma oxidized low-density lipoprotein (ox-LDL), nitric oxide (NO) and circulating endothelial cells (CEC) were measured. The brachial arterial hyperemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilatations were measured by high resolution ultrasound. These variables were analyzed before and after 3 months therapy.
RESULTSPlasma NO and FMD was significantly increased after 3 months therapy than before therapy [(80.46 +/- 10.24) micromol/Lvs (48.46 +/- 12.24) micromol/L, P < 0.01; (13.46 +/- 1.20)% vs (7.45 +/- 1.02)%, P < 0.05, respectively], while the number of CEC and ox-LDL were significantly decreased (P < 0.01) in P group. These values were similar before and after 3 months in C group. The linear correlation analysis showed that plasma ox-LDL negatively correlated with NO (r = -0.574, P < 0.01) and FMD (r = -0.517, P < 0.01) and positively correlated with CEC (r = 0.385, P < 0.01) in patients received 3 months probucol therapy.
CONCLUSIONSChronic antioxidant probucol therapy could improve endothelial function in patients with ACS.
