Elevated serum secretory type II phospholipase A2 in patients with coronary heart disease.
- Author:
Lu YU
1
;
Wen-bing JIANG
;
Guo-sheng FU
;
Guang-ming QIN
;
Jun-hong WANG
;
Zhao-quan HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; C-Reactive Protein; metabolism; Coronary Angiography; Coronary Disease; blood; diagnostic imaging; Female; Group II Phospholipases A2; Humans; Interleukin-8; blood; Lysophospholipids; blood; Male; Middle Aged; Phospholipases A; blood; Phospholipases A2
- From: Chinese Journal of Cardiology 2006;34(9):812-815
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo measure the serum level of secretory type II phospholipase A2 (sPLA2) in patients with coronary heart disease and investigate the possible relationship with IL-8 and LPA.
METHODSA total of 110 patients with acute coronary syndrome (ACS), 63 patients with stable coronary heart disease (SCHD) group and 89 non-CHD control patients were studied. Serum levels of sPLA2, IL-8, LPA and hs-CRP were measured and the correlation among these parameters was observed.
RESULTSThe levels of serum sPLA2 [(68 +/- 17) U/ml], IL-8 [(182 +/- 80) pg/ml] and LPA [(2.85 +/- 0.36) micromol/L] were significantly higher in CHD patients than those in controls [sPLA2: (55 +/- 12) U/ml; IL-8: (119 +/- 33) pg/ml; LPA: (2.34 +/- 0.36) micromol/L, all P < 0.01], and sPLA2 and IL-8 were also significantly higher in ACS patients [sPLA2: (71 +/- 18) U/ml; IL-8: (195 +/- 78) pg/ml] than those in SCHD patients [sPLA2: (63 +/- 12) U/ml; IL-8: (159 +/- 79) pg/ml, both P < 0.01]. Serum sPLA2 level was positively correlated with hs-CRP, IL-8 and LPA (r = 0.203, P = 0.007; r = 0.658, P < 0.01; r = 0.231, P = 0.005, respectively). The relative risk of having CHD is 6.248 (P < 0.01) with the sPLA2 level above 63.75 U/ml.
CONCLUSIONElevated serum sPLA2 level is a risk factor for CHD.
