The role of cyclooxygenase on angiogenesis and endothelial progenitor cell mobilization in rat ischemic myocardium.
- Author:
Jian ZHOU
1
;
Lan HUANG
;
Jun JIN
;
Xiao-jing WU
;
Yu-qiang FANG
;
Ming-bao SONG
;
Gang ZHAO
;
Xiao-hui ZHAO
;
Yin-pin ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cyclooxygenase 2; biosynthesis; Cyclooxygenase Inhibitors; pharmacology; Endothelial Cells; cytology; Female; Hypoxia-Inducible Factor 1, alpha Subunit; biosynthesis; Myocardial Infarction; drug therapy; pathology; Neovascularization, Physiologic; drug effects; Random Allocation; Rats; Rats, Sprague-Dawley; Stem Cells; metabolism; Vascular Endothelial Growth Factor A; blood
- From: Chinese Journal of Cardiology 2006;34(9):833-836
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of COX1 and COX2 on angiogenesis and endothelial progenitor cell mobilization in rats with experimental myocardial infarction (MI).
METHODSThe rats were randomly divided into 3 groups: MI group, MI plus rofecoxib group and MI plus valeryl salicylate group. At the 7th day after operation, circulating EPCs, plasma VEGF and HIF-1alpha mRNA of ischemic myocardium were measured. At the 28th day post operation, capillary densities were also measured in ischemic myocardium.
RESULTCompared with the MI group and the MI plus valeryl salicylate group, circulating EPCs, plasma VEGF, HIF-1alpha mRNA and capillary densities of ischemic myocardium were all decreased in MI plus rofecoxib group.
CONCLUSIONThe present study revealed that COX2 play an important role with angiogenesis and endothelial progenitor cell mobilization in rat with experimental MI by modulating expression of VEGF and HIF-1alpha.
