Foxp3 expression in CD4CD25Foxp3regulatory T cells promotes development of colorectal cancer by inhibiting tumor immunity.
- Author:
Xiao-Wen ZHU
1
;
Hai-Zhen ZHU
1
;
You-Qing ZHU
1
;
Mao-Hui FENG
2
;
Jian QI
1
;
Zhi-Fen CHEN
3
Author Information
1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
2. Department of Surgical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
3. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. zhfchen818@sina.com.
- Publication Type:Journal Article
- Keywords:
CD4+CD25+Foxp3+ regulatory T cells;
Foxp3;
IL-10;
Stat3;
colorectal cancer;
tumor immunity
- MeSH:
Adult;
Aged;
CD4-Positive T-Lymphocytes;
immunology;
Colorectal Neoplasms;
genetics;
immunology;
pathology;
Female;
Forkhead Transcription Factors;
biosynthesis;
genetics;
immunology;
Gene Expression Regulation, Neoplastic;
immunology;
Humans;
Immunity;
genetics;
Interleukin-10;
biosynthesis;
immunology;
Interleukin-2 Receptor alpha Subunit;
immunology;
Lymphatic Metastasis;
Male;
Middle Aged;
STAT3 Transcription Factor;
biosynthesis;
immunology;
T-Lymphocytes, Regulatory;
immunology
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2016;36(5):677-682
- CountryChina
- Language:English
-
Abstract:
The mechanism underlying CD4CD25Foxp3regulatory T cells (Tregs) promoting the development of colorectal cancer (CRC) was elucidated in the present study. Forty-eight cases of colorectal carcinomas, 22 cases of colon polyps and 21 cases of normal colorectal tissues were collected. The correlation among Foxp3, IL-10 and Stat3, and the clinical relevance of these three indexes were analyzed. The results showed that the levels of Foxp3 expressed in infiltrating CD4CD25Foxp3Tregs, and IL-10 and Stat3 in CRC tissues were all significantly higher than those in polypus tissues and normal colon tissues (P< 0.01). Pearson correlation analysis indicated that the expression level of Foxp3 was positively correlated with Stat3 at mRNA level (r=0.526, P=0.036), and was positively correlated with IL-10 at protein level (r=0.314, P=0.030). The Foxp3 expressed in CD4CD25Foxp3Tregs was correlated with the histological grade, lymph node metastasis and TNM stage of CRC (P<0.05 for all). The IL-10 expression was correlated with the histological grade and TNM stage (both P<0.05). The Stat3 expression was correlated with the lymph node metastasis and TNM stage (both P<0.05). It was concluded that CD4CD25Foxp3Tregs can inhibit tumor immunity in combination with some other related inhibitory cytokines and that Foxp3 expression in CD4CD25Foxp3Tregs correlates with CRC progression.
