Expression of IL-17 and Syndecan-1 in Nasal Polyps and Their Correlation with Nasal Polyps
10.1007/s11596-017-1749-1
- Author:
GONG GUO-QING
1
;
REN FANG-FANG
;
WANG YAN-JUN
;
WAN LANG
;
CHEN SHAN
;
YUAN JIE
;
YANG CHUAN-MEI
;
LIU BANG-HUA
;
KONG WEI-JIA
Author Information
1. Department of Otolaryngology
- Keywords:
interleukin-17;
syndecan-1;
nasal polyps
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2017;37(3):412-418
- CountryChina
- Language:Chinese
-
Abstract:
Nasal polyp (NP) is a common chronic inflammatory disease of the nasal cavity and sinuses.Although some authors have suggested that NP is related to inflammatory factors such as interleukin (IL)-1β,IL-5,IL-8,granulocyte-macrophage colony-stimulating factor (GM-CSF),tumor necrosis factor (TNF)-α,and IL-17,the mechanisms underlying the pathogenesis and progression of NP remain obscure.This study investigated the expression and distribution of IL-17 and syndecan-1 in NP,and explored the roles of these two molecules in the pathogenesis of eosinophilic chronic rhinosinusitis with nasal polyps (Eos CRSwNP) and non-Eos CRSwNP.Real-time PCR and immunohistochemistry were used to detect the expression of IL-17 and syndecan-1 in samples [NP,unciform process (UP) from patients with CRS,and middle turbinate (MT) from healthy controls undergoing pituitary tumor surgery].The results showed that the expression levels of IL-17 and syndecan-1 were upregulated in both NP and UP tissues,but both factors were higher in NP tissues than in UP tissues.There was no significant difference in IL-17 levels between the Eos CRSwNP and non-Eos CRSwNP samples,and syndecan-1 levels were increased in the non-Eos CRSwNP tissues as compared with those in Eos CRSwNP tissues.In all of the groups,there was a close correlation between the expression of IL-17 and syndecan-1 in nasal mucosa epithelial cells,glandular epithelial cells,and inflammatory cells,suggesting that IL-17 and syndecan-1 may play a role,and interact with each other,in the pathogenesis ofnon-Eos CRSwNP.
