Influence of some extrinsic factors on the stability of water-soluble carboxymethyl chitosan.
- Author:
Weiying ZHANG
1
;
Jiqian ZHU
;
Zheng XU
;
Qisheng GU
Author Information
1. Department of Materials Science & Engineering, Tongji University, Shanghai 200092, China.
- Publication Type:Journal Article
- MeSH:
Chitosan;
chemical synthesis;
chemistry;
Drug Stability;
Hydrogen-Ion Concentration;
Solubility;
Temperature
- From:
Journal of Biomedical Engineering
2005;22(4):745-748
- CountryChina
- Language:Chinese
-
Abstract:
Water-soluble carboxymethyl chitosan was prepared from dried shrimp shells. The intrinsic viscosities of its samples were measured to evaluate the stability of carboxymethyl chitosan. The influential factors of stability, such as heat, pH, ionic strength, ultraviolet radiation, and sterilization were studied. The results demonstrate that the intrinsic viscosities of water-soluble chitosan will be influenced, to a certain extent, by the change of pH and ionic strength. Ultraviolet radiation and sterilized processes not only exept influence on the degradation of chitosan, but also have prominent effects on the molecular structure of it. Besides, temperature will also affect the speed of degradation, and chitosan can be stored at a temperature as low as 2 degrees C-8 degrees C.
