Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats.
- Author:
Hui HUANG
1
;
Jingyi FU
;
Haoming TIAN
Author Information
1. Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetes Mellitus, Experimental;
metabolism;
Enalapril;
pharmacology;
Kidney;
metabolism;
Male;
Proteinuria;
metabolism;
Proto-Oncogene Proteins c-sis;
metabolism;
Quercetin;
pharmacology;
Random Allocation;
Rats;
Rats, Wistar;
Vascular Endothelial Growth Factor A;
metabolism
- From:
Journal of Biomedical Engineering
2005;22(4):791-794
- CountryChina
- Language:Chinese
-
Abstract:
This study sought to assess the effects of Quercetin and Enalapril on urinary protein excretion and amount of platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor-1 (VEGF-1) in renal tissue of diabetic rats. 29 streptozotocin-induced diabetic rats were divided into 3 groups, diabetic control group (group D, n=12); Enalapril group (group E, n=10); Quercetin group (group Q, n=7). In addition, there was one normal control group (group N, n = 5). The urinary protein excretion of 24 hours was measured at 4, 8, 12 weeks. All rats were sacrificed at 12 weeks. The amounts of PDGF-B and VEGF-1 in renal tissue were measured by immunohistochemical techniques. The 24-h levels of urinary protein excretion of D,Q and E groups were higher than that of N group; the level of Q, E groups were lower than that of D group; there was no difference between Q and E group. The expression levels of PDGF-B and VEGF-1 in renal tissue of D, Q, and E groups were significantly higher than that of N group the levels of Q and E groups were significantly lower than that of D group, no difference was found between Q and E group. The protective role of Quercetin and Enalapril in lowering urinary protein excretion may be related to the decreased amounts of PDGF-B and VEGF-1 in renal tissue.
