Impedance effects of interleukin-6 on cyclophosphamide-induced hematopoietic damnification in dogs.
- Author:
Hailin YIN
1
;
Xueling HE
;
Xu BAO
;
Xuexu LIU
;
Guangwu YANG
Author Information
1. Laboratory Animal Center of Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bone Marrow Cells;
drug effects;
metabolism;
Cyclophosphamide;
adverse effects;
Dogs;
Female;
Interleukin-6;
pharmacology;
therapeutic use;
Leukopenia;
chemically induced;
prevention & control;
Male;
Thrombocytopenia;
chemically induced;
prevention & control
- From:
Journal of Biomedical Engineering
2005;22(4):798-801
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study is to evaluate the effect of Interleukin-6 on cyclophosphamide-induced hematopoietic damnification. The doses of Interleukin-6 in 3 different regimens were hypodermally injected into dogs for 7 days respectively to establish the cyclophosphamide-induced hematopoietic damnification model. The effect of Interleukin-6 on the production of platelets and the amount of other cells in the dogs' bone marrow were determined on the 21st day. The results showed that Interleukin-6 significantly alleviated the reduction of platelet count and recovered the platelets level faster. The impedance effects of Interleukin-6 directed against hematopoietic damnification of bone marrow and spleen were shown by pathological examination. These suggest that the Interleukin-6 can significantly impede cyclophosphamide-induced hematopoietic damnification.
