A new loading bioreactor for bone tissue-engineering applications.
- Author:
Chunqi ZHANG
1
;
Xizheng ZHANG
;
Furong WANG
;
Jinhui WU
;
Yuexin WANG
;
Qingfei LU
Author Information
1. Institute of Medical Equipment, Academy of Military Medical Science, Tianjin, China. zchunqiu@sohu.com
- Publication Type:Journal Article
- MeSH:
Bioreactors;
Bone and Bones;
cytology;
Cell Differentiation;
Cells, Cultured;
Humans;
Mechanotransduction, Cellular;
Osteoblasts;
cytology;
metabolism;
Stress, Mechanical;
Tissue Engineering;
instrumentation;
methods;
Tissue Scaffolds
- From:
Journal of Biomedical Engineering
2005;22(4):804-832
- CountryChina
- Language:Chinese
-
Abstract:
Bone cells live in an environment heavily influenced by mechanical force. The development of bone tissue is dependent on the environment that surrounds it, both in vivo and in vitro. A loading stimulator on research of bone tissue-engineering was developed based on the mechanism of mechanosensation, scaffolding composites with mechanical strains with more physiologic magnitude, frequency components, and waveform. It also achieves the mechanical environment particularly in hard scaffold enough strong like cancellous bone. The device was tested using a reference scaffold made of better elastic plastic material. The experiment results showed that the device could be used in precision strain controls. Since the drive of the stimulator comes from the usage of smart material, piezoceramics, the strain at physiological level is controlled precisely. The stimulator provides a mechanical condition under which the effects of loading applied on bone tissue-engineering culture are conveniently investigated. Furthermore, after the stimulator is improved, it will be an appropriate bioreactor for bone tissue-engineering culture.
