Experimental study of the lethal effects of steep pulsed electric field on cancer cells in BALB/c mice.
- Author:
Chenguo YAO
1
;
Caixin SUN
;
Yan MI
;
Lan XIONG
;
Ya HU
;
Lina HU
Author Information
1. Key Lab of High Voltage Engineering and Electrical New Technology, Ministry of Education, Chongqing University, Chongqing 400044, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Line, Tumor;
Cell Proliferation;
Electromagnetic Fields;
Electroporation;
methods;
Female;
Mice;
Mice, Inbred BALB C;
Neoplasm Transplantation;
Uterine Cervical Neoplasms;
pathology
- From:
Journal of Biomedical Engineering
2005;22(5):896-900
- CountryChina
- Language:Chinese
-
Abstract:
This study was conducted to observe the lethal effects of steep pulsed electric field(SPEF) on the cancerous squamous cells in BALB/c mice. Female mice were inoculated with the solution of cervical cancer cells line. The tumor-bearing mice of the experiment group were exposed to SPEF. Then, the histomorphological changes were examined and compared between experiment group and control group. The histological and antitumor assay showed that SPEF could selectively injure tumor cells and inhibit cell proliferation. After treatment, pyknosis, karyoclasis and karyolysis of cancer cells were observed under light and electron mircroscope. More serious changes appeared some days later. These results indicate that SPEF have lethal effects on cervical cancer. It may prolong the survival period of tumor-bearing mice.
