Research of the hemostasis effect of chitosan acetic acid solution.
- Author:
Feng TIAN
1
;
Jian YANG
;
Shiqian CHEN
;
Yaodong KAN
;
Fengxiang JI
Author Information
1. The Institute of Medical Equipment, Academy of Military Medical Science, Tianjin 300161, China. tianfeng56754@eyon.com
- Publication Type:Journal Article
- MeSH:
Acetic Acid;
chemistry;
pharmacology;
Animals;
Chitosan;
chemistry;
pharmacology;
Fibrinogen;
analysis;
Hemostatics;
chemistry;
pharmacology;
Partial Thromboplastin Time;
Prothrombin Time;
Rabbits;
Thrombin Time
- From:
Journal of Biomedical Engineering
2005;22(5):999-1003
- CountryChina
- Language:Chinese
-
Abstract:
The effect of chitosan with different molecular weight and deacetylation degree on blood hemostasis was tested. The experiments found evident alteration of red blood cell morphology and unusual coagglutination between erythrocytes in the anticoagulant blood which was treated by chitosan acetic acid solution. The red blood cells clot formation experiments showed that chitosan with low deacetylation degree (60%-70%) caused more red blood cells to assemble when compared versus chitosan with other deacetylation degrees. The effect of molecular weight between 10(5)-10(6) was not obvious. The thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), and concentration of fibrinogen (FIB) of blood treated by chitosan acetic acid solution were measured. The results proved that the hemostasis property of chitosan acetic acid solution was independent of the platelets and the normal "Cascade-like" coagulation pathway.
