Restoring the skin from traumatism by means of collagen-konjac glucomannan-chondroitin sulfate blend film.
- Author:
Xuexu LIU
1
;
Kunyu WANG
;
Yunping DING
;
Xueling HE
;
Bi WANG
Author Information
1. Laboratory Animal Center of Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Chondroitin Sulfates;
therapeutic use;
Collagen;
therapeutic use;
Female;
Male;
Mannans;
therapeutic use;
Membranes, Artificial;
Rabbits;
Skin;
injuries;
Skin Ulcer;
drug therapy;
Wound Healing;
drug effects
- From:
Journal of Biomedical Engineering
2005;22(5):1004-1023
- CountryChina
- Language:Chinese
-
Abstract:
This study aims at restoring the skin from traumatism by use of the collagen(from piglet skin) and konjac glucomannan-chondroitin sulfate blend film. The 2 cm x 4 cm skin traumatism model was established on both sides of the waist spinal column in 14 New Zealand rabbits each weighing 1.5-2.0 kg. One side was covered with blend film, the other side was used as a control. Then the changes of the skin traumatism were observed at different time-points after the operation, the wound tissue samples were taken for histological examination. The blend film could prevent skin traumatism from bleeding and infection. The skin traumatism treated by blend film showed signs of rectangle scab and the control showed signs of linear scab after healing. No obvious immune rejection was seen. The collagen-konjac glucomannan-chondroitin sulfate blend film can accelerate the restoration of skin from traumatism.
