Development of a piezoelectric sensor for detection of low endotoxin concentration.
- Author:
Xingliang XIONG
1
;
Xiang WANG
;
Shaoxi CAI
Author Information
1. Key Lab of Biomechanical & Tissue Engineering, Ministry of Education, Chongqing University, Chongqing 400044, China. xxlsober@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Biosensing Techniques;
instrumentation;
Endotoxins;
analysis;
Equipment Design;
Quartz;
Rabbits
- From:
Journal of Biomedical Engineering
2005;22(5):1040-1044
- CountryChina
- Language:Chinese
-
Abstract:
Endotoxin is an important factor which can lead to endotoxemia and complication. Accurate detection of its concentration is very useful for the diagnosis and treatment of these diseases. A piezoelectric biosensor for detecting endotoxin was developed, which was based on liquid damping effect of quartz crystal resonator. The test results showed that the maximal frequency shift of sensor is linearly dependent on the logarithm value of concentration of endotoxin (0.1 pg/m - 10 ng/ml). The time which d (deltaf)/dt(maax) appeared in frequency shift curve was also linearly dependent on the logarithm value of concentration of endotoxin (0.01 pg/ml - 10 ng/ml). The detection time was shortened and the minimal limit of detection was decreased using the second method. Thus the proposed sensor is much simpler, more precise and has more lower limit of detecting detection of endotoxin when compared with the conventional methods.
