New thoughts in mechanism research of acupuncture for myocardial stunning from κ-opioid receptor signaling pathway.

Author: Yuanyuan WANG ¹ ; Qun LIU ¹ ; Fengyan LU ¹ ; Juanjuan XIN ¹ ; Qiufu DAI ¹ ; Shuyang WU ¹ ; Yuxue ZHAO ¹ ; Junhong GAO ¹ ; Xiaochun YU ¹
Author Information

1. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Publication Type:Journal Article
Keywords: acupuncture; myocardial stunning; κ-opioid receptor
From: Chinese Acupuncture & Moxibustion 2018;38(1):77-81
CountryChina
Language:Chinese
Abstract: By reviewing the literature regarding the development mechanism of myocardial stunning, effects of acupuncture on myocardial ischemic injury, and correlation between acupuncture and κ-opioid receptor, it was suggested that acupuncture was highly likely to act on κ-opioid receptor in myocardial cells, and directly treated myocardial malfunction induced by myocardial stunning through κ-opioid receptor and its signaling pathway. In addition, acupuncture could inhabit the signaling pathway of adrenoceptor β1, one of the main functional receptors, to indirectly improve myocardial ischemic injury. From κ-opioid receptor signaling pathway, the action mechanism of acupuncture for prevention and treatment of myocardial stunning was discussed in this paper, hoping to provide new ideas for possible mechanism of acupuncture for myocardial ischemic injury.