Isolated Central Nervous System Relapse of Acute Lymphoblastic Leukemia.
10.14791/btrt.2014.2.2.114
- Author:
Sang Hyun SUNG
1
;
In Seok JANG
Author Information
1. Department of Neurosurgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Science, Seoul, Korea. 20100049@kirams.re.kr
- Publication Type:Case Report
- Keywords:
Leukemia;
Central nervous system;
Recurrence
- MeSH:
Biopsy;
Bone Marrow;
Brain;
Central Nervous System*;
Child;
Dizziness;
Drug Therapy;
Female;
Headache;
Hematologic Neoplasms;
Hematoma;
Hemianopsia;
Humans;
Incidence;
Leukemia;
Magnetic Resonance Imaging;
Neurologic Examination;
Occipital Lobe;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Precursor Cells, B-Lymphoid;
Rabeprazole;
Recurrence*;
Visual Fields;
Vomiting
- From:Brain Tumor Research and Treatment
2014;2(2):114-118
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer and may exhibit central nervous system (CNS) involvement. Advances in chemotherapy and effective CNS prophylaxis have significantly decreased the incidence of CNS relapse of ALL to 5-10%. Here, we report the case of a patient with isolated CNS relapse of standard risk group pre-B-cell type ALL in an 11-year-old girl, relapsed 3 years after successful completion of chemotherapy. An 11-year-old girl visited our hospital complaining of headache, dizziness, vomiting, and visual field defects. Neurological examination revealed left-side homonymous hemianopsia. Brain magnetic resonance imaging showed a large irregular dural-based sulcal hematoma in the right parietal and occipital lobes. Surgery to remove the hematoma revealed the existence of hematopoietic malignancy after pathologic evaluation. Bone marrow biopsy was subsequently performed but showed no evidence of malignancy.
