Assessment of curative effect on erectile dysfunction of two drugs.
- Author:
Da-Zhong YANG
1
;
Xiao-Nian MA
;
Zuo-Jun YU
;
Yu JIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adrenergic alpha-Antagonists; therapeutic use; Double-Blind Method; Erectile Dysfunction; drug therapy; Humans; Male; Phentolamine; therapeutic use; Piperazines; therapeutic use; Purines; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Treatment Outcome; Vasodilator Agents; therapeutic use
- From: National Journal of Andrology 2003;9(4):260-262
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo further discuss the method of evaluating curative effect on erectile dysfunction(ED).
METHODSClinical trials(Phase II) of sildenafil and phentolamine were both 8-week-long, randomized, double-blind and placebo-controlled. Not only the curative effect between each treatment group and placebo group but also between the treatment groups were compared. The dosage of sildenafil and phentolamine was respectively 50-100 mg and 40 mg.
RESULTSEfficiency, success rate of sexual intercourse and general curative effect in sildenafil and phentolamine groups were respectively 79.17%, 75.00%, 83.33% and 52.38%, 85.71%, 52.38%. The result revealed a statistically significant (P < 0.05) improvement over placebo. But no obvious differences were shown between the two treatment groups(P > 0.05).
CONCLUSIONSMost assessments of curative effect of ED drugs come from questionnaires answered subjectively by patients. The Lack of objective assessment criteria way lead to the non-conformity between trial results and clinical practices. So the curative effect of drugs shall be assessed more accurately and from more perspectives.
